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1

Mass spectrometry analysis of HIV-1 Vif reveals an increase in ordered structure upon oligomerization in regions necessary for viral infectivity

Jared R. Auclair, Karin M. Green, Shivender Shandilya, James E. Evans, Mohan Somasundaran, Celia A. Schiffer

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2007

Language:

english

File:

PDF, 2.95 MB

english, 2007

2

Composition and biological activity of traditional and commercial kava extracts

Cynthia S. Côté, Christine Kor, Jon Cohen, Karine Auclair

Journal:

Biochemical and Biophysical Research Communications

Year:

2004

Language:

english

File:

PDF, 458 KB

english, 2004

3

Dual use of a chemical auxiliary: molecularly imprinted polymers for the selective recovery of products from biocatalytic reaction mixtures

Larsen, Aaron T., Lai, Tiffany, Polic, Vanja, Auclair, Karine

Journal:

Green Chemistry

Year:

2012

Language:

english

File:

PDF, 1.36 MB

english, 2012

4

Highly Efficient P(III)-to-P(V) Oxidative Rearrangement

Gao, Feng, Auclair, Karine

Journal:

Phosphorus Sulfur and Silicon and the Related Elements

Year:

2006

Language:

english

File:

PDF, 193 KB

english, 2006

5

Solvent-free enzyme activity: quick, high-yielding mechano-enzymatic hydrolysis of cellulose into glucose

Hammerer, Fabien, Loots, Leigh, Do, Jean-Louis, Therien, J. P. Daniel, Nickels, Christopher W., Friscic, Tomislav, Auclair, Karine

Journal:

Angewandte Chemie International Edition

Year:

2018

Language:

english

File:

PDF, 975 KB

english, 2018

6

Solvent-free enzyme activity: quick, high-yielding mechano-enzymatic hydrolysis of cellulose into glucose

Hammerer, Fabien, Loots, Leigh, Do, Jean-Louis, Therien, J. P. Daniel, Nickels, Christopher W., Friscic, Tomislav, Auclair, Karine

Journal:

Angewandte Chemie

Year:

2018

Language:

english

File:

PDF, 975 KB

english, 2018

7

Regio- and Chemoselective 6′-N-Derivatization of Aminoglycosides: Bisubstrate Inhibitors as Probes To Study Aminoglycoside 6′-N-Acetyltransferases

Feng Gao, Xuxu Yan, Oliver M. Baettig, Albert M. Berghuis, Karine Auclair

Journal:

Angewandte Chemie

Year:

2005

Language:

english

File:

PDF, 141 KB

english, 2005

8

Regio- and Chemoselective 6′-N-Derivatization of Aminoglycosides: Bisubstrate Inhibitors as Probes To Study Aminoglycoside 6′-N-Acetyltransferases

Feng Gao, Xuxu Yan, Oliver M. Baettig, Albert M. Berghuis, Karine Auclair

Journal:

Angewandte Chemie International Edition

Year:

2005

Language:

english

File:

PDF, 142 KB

english, 2005

9

Activity of human P450 2D6 in biphasic solvent systems

Jin Zhao, Elaine Tan, Julian Ferras, Karine Auclair

Journal:

Biotechnology and Bioengineering

Year:

2007

Language:

english

File:

PDF, 216 KB

english, 2007

10

The activity of human CYP2D6 in low water organic solvents

Jin Zhao, Karine Auclair

Journal:

Biotechnology and Bioengineering

Year:

2009

Language:

english

File:

PDF, 181 KB

english, 2009

11

Replacement of Natural Cofactors by Selected Hydrogen Peroxide Donors or Organic Peroxides Results in Improved Activity for CYP3A4 and CYP2D6

Amandine Chefson, Jin Zhao, Karine Auclair

Journal:

Year:

2006

Language:

english

File:

PDF, 160 KB

english, 2006

12

CYP3A4 Activity in the Presence of Organic Cosolvents, Ionic Liquids, or Water-Immiscible Organic Solvents

Amandine Chefson, Karine Auclair

Journal:

Year:

2007

Language:

english

File:

PDF, 330 KB

english, 2007

13

Replacement of Natural Cofactors by Selected Hydrogen Peroxide Donors or Organic Peroxides Results in Improved Activity for CYP3A4 and CYP2D6

Amandine Chefson, Jin Zhao, Karine Auclair

Journal:

Year:

2007

File:

PDF, 20 KB

2007

14

Elucidating Protein Binding Mechanisms by Variable-c ITC

Lee A. Freiburger, Karine Auclair, Anthony K. Mittermaier

Journal:

Year:

2009

Language:

english

File:

PDF, 235 KB

english, 2009

15

Synthesis of a Phosphonate-Linked Aminoglycoside–Coenzyme A Bisubstrate and Use in Mechanistic Studies of an Enzyme Involved in Aminoglycoside Resistance

Feng Gao, Xuxu Yan, Karine Auclair

Journal:

Chemistry - A European Journal

Year:

2009

Language:

english

File:

PDF, 580 KB

english, 2009

16

ChemInform Abstract: Conversion of Cyclic Nonaketides to Lovastatin and Compactin by a lovC Deficient Mutant of Aspergillus terreus.

Karine Auclair, Jonathan Kennedy, C. Richard Hutchinson, John C. Vederas

Journal:

Year:

2001

File:

PDF, 24 KB

2001

17

Inhibition of Aminoglycoside-Deactivating Enzymes APH(3′)-IIIa and AAC(6′)-Ii by Amphiphilic Paromomycin O2′′-Ether Analogues

Dr. Janek Szychowski, Dr. Jiro Kondo, Omar Zahr, Prof. Karine Auclair, Prof. Eric Westhof, Prof. Stephen Hanessian, Prof. Jeffrey W. Keillor

Journal:

Year:

2011

Language:

english

File:

PDF, 590 KB

english, 2011

18

Inside Cover: Inhibition of Aminoglycoside-Deactivating Enzymes APH(3′)-IIIa and AAC(6′)-Ii by Amphiphilic Paromomycin O2′′-Ether Analogues (ChemMedChem 11/2011)

Dr. Janek Szychowski, Dr. Jiro Kondo, Omar Zahr, Prof. Karine Auclair, Prof. Eric Westhof, Prof. Stephen Hanessian, Prof. Jeffrey W. Keillor

Journal:

Year:

2011

File:

PDF, 1.18 MB

2011

19

The use of aminoglycoside derivatives to study the mechanism of aminoglycoside 6′-N-acetyltransferase and the role of 6′-NH2 in antibacterial activity

Xuxu Yan, Feng Gao, Sirilata Yotphan, Parseh Bakirtzian, Karine Auclair

Journal:

Bioorganic & Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 181 KB

english, 2007

20

Geminal dialkyl derivatives of N-substituted pantothenamides: Synthesis and antibacterial activity

T. Olukayode Akinnusi, Kenward Vong, Karine Auclair

Journal:

Bioorganic & Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 1.06 MB

english, 2011

21

Synthesis and use of sulfonamide-, sulfoxide-, or sulfone-containing aminoglycoside–CoA bisubstrates as mechanistic probes for aminoglycoside N-6′-acetyltransferase

Feng Gao, Xuxu Yan, Omar Zahr, Aaron Larsen, Kenward Vong, Karine Auclair

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 423 KB

english, 2008

22

Conversion of cyclic nonaketides to lovastatin and compactin by a lovc deficient mutant of Aspergillus terreus

Karine Auclair, Jonathan Kennedy, C.Richard Hutchinson, John C Vederas

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 274 KB

english, 2001

23

Competing allosteric mechanisms modulate substrate binding in a dimeric enzyme

Freiburger, Lee A, Baettig, Oliver M, Sprules, Tara, Berghuis, Albert M, Auclair, Karine, Mittermaier, Anthony K

Journal:

Nature Structural and Molecular Biology

Year:

2011

Language:

english

File:

PDF, 840 KB

english, 2011

24

Aspects of the biosynthesis of non-aromatic fungal polyketides by iterative polyketide synthases

C. Richard Hutchinson, Jonathan Kennedy, Cheonseok Park, Steven Kendrew, Karine Auclair, John Vederas

Journal:

Antonie van Leeuwenhoek

Year:

2000

Language:

english

File:

PDF, 169 KB

english, 2000

25

An Overview of Molecular Spectroscopic Studies on Theobromine and Related Alkaloids

Tewari, Brij B., Beaulieu-Houle, Guillaume, Larsen, Aaron, Kengne-Momo, Rosine, Auclair, Karine, Butler, Ian S.

Journal:

Applied Spectroscopy Reviews

Year:

2012

Language:

english

File:

PDF, 835 KB

english, 2012

26

Van ‘t Hoff global analyses of variable temperature isothermal titration calorimetry data

Lee A. Freiburger, Karine Auclair, Anthony K. Mittermaier

Journal:

Thermochimica Acta

Year:

2012

Language:

english

File:

PDF, 950 KB

english, 2012

27

Inhibition of human P450 enzymes by nicotinic acid and nicotinamide

Cédric Gaudineau, Karine Auclair

Journal:

Biochemical and Biophysical Research Communications

Year:

2004

Language:

english

File:

PDF, 226 KB

english, 2004

28

Inhibition of human P450 enzymes by multiple constituents of the Ginkgo biloba extract

Cédric Gaudineau, Rachel Beckerman, Sarah Welbourn, Karine Auclair

Journal:

Biochemical and Biophysical Research Communications

Year:

2004

Language:

english

File:

PDF, 280 KB

english, 2004

29

EWS-FLI1 inhibits TNFα-induced NFκB-dependent transcription in Ewing sarcoma cells

Julie Lagirand-Cantaloube, Karine Laud, Alain Lilienbaum, Franck Tirode, Olivier Delattre, Christian Auclair, Marie-Hélène Kryszke

Journal:

Biochemical and Biophysical Research Communications

Year:

2010

Language:

english

File:

PDF, 387 KB

english, 2010

30

P1-162 Progress towards the synthesis of a stable alpha-helical amyloid-β peptide

Karine Auclair, Christine Kor, Stephen Jackson, Samia Ait-Mohand, Dominique Bernard

Journal:

Neurobiology of Aging

Year:

2004

Language:

english

File:

PDF, 155 KB

english, 2004

31

Cloning and expression of a heme binding protein from the genome of Saccharomyces cerevisiae

Karine Auclair, Hong-Wei Huang, Pierre Moënne-Loccoz, Paul R. Ortiz de Montellano

Journal:

Protein Expression and Purification

Year:

2003

Language:

english

File:

PDF, 465 KB

english, 2003

32

Understanding and overcoming aminoglycoside resistance caused by N-6′-acetyltransferase

Vong, Kenward, Auclair, Karine

Journal:

Year:

2012

Language:

english

File:

PDF, 906 KB

english, 2012

33

Sugar-mediated lyoprotection of purified human CYP3A4 and CYP2D6

Amandine Chefson, Jin Zhao, Karine Auclair

Journal:

Journal of Biotechnology

Year:

2007

Language:

english

File:

PDF, 266 KB

english, 2007

34

Synthesis of 4′-aminopantetheine and derivatives to probe aminoglycoside N-6′-acetyltransferase

Yan, Xuxu, Akinnusi, T. Olukayode, Larsen, Aaron T., Auclair, Karine

Journal:

Organic & Biomolecular Chemistry

Year:

2011

Language:

english

File:

PDF, 398 KB

english, 2011

35

Type II Ligands as Chemical Auxiliaries To Favor Enzymatic Transformations by P450 2E1

Ménard, Amélie, Fabra, Camilo, Huang, Yue, Auclair, Karine

Journal:

Year:

2012

Language:

english

File:

PDF, 912 KB

english, 2012

36

Predictable Stereoselective and Chemoselective Hydroxylations and Epoxidations with P450 3A4

Larsen, Aaron T., May, Erin M., Auclair, Karine

Journal:

Journal of the American Chemical Society

Year:

2011

Language:

english

File:

PDF, 897 KB

english, 2011

37

Progress towards the easier use of P450 enzymes

Chefson, Amandine, Auclair, Karine

Journal:

Molecular BioSystems

Year:

2006

Language:

english

File:

PDF, 370 KB

english, 2006

38

Inhibitors of Aminoglycoside Resistance Activated in Cells

Vong, Kenward, Tam, Ingrid S., Yan, Xuxu, Auclair, Karine

Journal:

ACS Chemical Biology

Year:

2012

Language:

english

File:

PDF, 1.95 MB

english, 2012

39

Synthesis and Structure−Activity Relationships of Truncated Bisubstrate Inhibitors of Aminoglycoside 6‘- N -Acetyltransferases

Gao, Feng, Yan, Xuxu, Shakya, Tushar, Baettig, Oliver M., Ait-Mohand-Brunet, Samia, Berghuis, Albert M., Wright, Gerard D., Auclair, Karine

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 145 KB

english, 2006

40

Exploring structural motifs necessary for substrate binding in the active site of Escherichia coli pantothenate kinase

Awuah, Emelia, Ma, Eric, Hoegl, Annabelle, Vong, Kenward, Habib, Eric, Auclair, Karine

Journal:

Bioorganic & Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 1.70 MB

english, 2014

41

Stereochemical modification of geminal dialkyl substituents on pantothenamides alters antimicrobial activity

Hoegl, Annabelle, Darabi, Hamed, Tran, Elisa, Awuah, Emelia, Kerdo, Eleanor S.C., Habib, Eric, Saliba, Kevin J., Auclair, Karine

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2014

Language:

english

File:

PDF, 625 KB

english, 2014

42

Revisiting the Mechanism of P450 Enzymes with the Radical Clocks Norcarane and Spiro[2,5]octane

Auclair, Karine, Hu, Zhengbo, Little, Dorothy M., Ortiz de Montellano, Paul R., Groves, John T.

Journal:

Journal of the American Chemical Society

Year:

2002

Language:

english

File:

PDF, 173 KB

english, 2002

43

Techniques in Organic Chemistry, Part 2: Videotape; Abstract of Special Issue 22

Browne, Lois M., Auclair, Karine

Journal:

Journal of Chemical Education

Year:

1998

Language:

english

File:

PDF, 163 KB

english, 1998

44

Solution 1 H, 15 N NMR Spectroscopic Characterization of Substrate-Bound, Cyanide-Inhibited Human Heme Oxygenase: Water Occupation of the Distal Cavity

Li, Yiming, Syvitski, Ray T., Auclair, Karine, Ortiz de Montellano, Paul, La Mar, Gerd N.

Journal:

Journal of the American Chemical Society

Year:

2003

Language:

english

File:

PDF, 566 KB

english, 2003

45

Controlling substrate specificity and product regio- and stereo-selectivities of P450 enzymes without mutagenesis

Polic, Vanja, Auclair, Karine

Journal:

Bioorganic & Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 4.28 MB

english, 2014

46

Roles of the Proximal Heme Thiolate Ligand in Cytochrome P450 cam

Auclair, Karine, Moënne-Loccoz, Pierre, Ortiz de Montellano, Paul R.

Journal:

Journal of the American Chemical Society

Year:

2001

Language:

english

File:

PDF, 122 KB

english, 2001

47

Site-Specific Fluorescent Labeling and Oriented Immobilization of a Triple Mutant of CYP3A4 via C64

Ménard, Amélie, Huang, Yue, Karam, Pierre, Cosa, Gonzalo, Auclair, Karine

Journal:

Bioconjugate Chemistry

Year:

2012

Language:

english

File:

PDF, 4.60 MB

english, 2012

48

Techniques in Organic Chemistry, Part 1: VHS Videotape; Abstract of Special Issue 20

Browne, Lois M., Auclair, Karine

Journal:

Journal of Chemical Education

Year:

1998

Language:

english

File:

PDF, 251 KB

english, 1998

49

1 H NMR Detection of Immobilized Water Molecules within a Strong Distal Hydrogen-Bonding Network of Substrate-Bound Human Heme Oxygenase-1

Syvitski, Ray T., Li, Yiming, Auclair, Karine, Ortiz de Montellano, Paul R., La Mar, Gerd N.

Journal:

Journal of the American Chemical Society

Year:

2002

Language:

english

File:

PDF, 120 KB

english, 2002

50

Kinetic and Structural Analysis of Bisubstrate Inhibition of the Salmonella enterica Aminoglycoside 6‘- N -Acetyltransferase †,‡

Magalhães, Maria L. B., Vetting, Matthew W., Gao, Feng, Freiburger, Lee, Auclair, Karine, Blanchard, John S.

Journal:

Year:

2008

Language:

english

File:

PDF, 277 KB

english, 2008